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KMID : 0378019920350080042
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New Medical Journal
1992 Volume.35 No. 8 p.42 ~ p.50
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A Clinical Study of Reactive Histiocytic Hyperplasia with Hemophagocytosis
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Abstract
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A total of 24 cases of reactive histiocytic hyperplasia with hemophagocytosis admitted to the Dongsan Medical Center, Keimyung University from January 1988 to June 1991. The results were summarized as follows.
1. These 24 patients ranged in age from 19 to 72 years with a median age of 44 years and it occurred most commonly in the 6th decade and more frequently in men.
2. Average annual incidence was b.9 cases and mean duration of hospital, stay was 22 days. 4 cases of mortality was founded (mortality rate: 17.4%).
3. Fever was the most consistant feature and other relatively common signs were hepatosplenomegaly, skin rash, purpura, and icteric skin.
4. Depression of peripheral blood counts was the most common laboratory abnormalities. Anemia, thrombocytopenia, and leukopenia occurred in 87.5%, 66.7% and 58.3% of patients respectively, but severe leukocytosis developed in 5 cases. Elevated serum transaminase levels were present in 62.5% of patients and serum immunoglobulin levels were abnormal in 4 of 9 patients tested : 3 had hypogammaglobulinemia and 1 had polyclonal gammopathy.
5. Bone marrow aspirates of all patients showed prominent phagocytosis of hematopoietic cells by histiocytes. 58.3% of patients had normocellularitiy and increased stored iron were present in 63.2%.
6. All of our patients had underlying illness. Non-Hodgkin´s lymphomas were present in 3 cases and others were 4 cases of tuberculosis, typhoid fever, subacute bacterial endocarditis and CNS lesion in 3 cases respectively, 2 cases of hematologic disease and membranous glomerulonephritis, TTP, diabetes, liver cirrhosis, collagen vascular disease, epidemic hemorrhagic fever in 1 case respectively.
7. Infections were present in 20 patients (80.3%) and causative organism were documented
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